Referrals: When should you refer and to whom

Referrals:  When should you refer and to whom

Diagnosis of pituitary disease is not straightforward.

There are a wide range of symptoms, reflecting the various conditions caused by a Pituitary tumour.  Some are specific and obvious but many are vague and may not point to the pituitary.

Most GPs see only one or two cases in their whole careers which compounds the problem.

The tables following list symptoms associated with various tumour types: more details are included in the specific sheets.

Whilst you would not want to send every patient with a headache to an Endocrinologist, those with high circulating Thyroxine and high TSH should be referred. To this end a list of basic tests is also included.

For Acromegaly & Prolactinoma especially, there should be a low threshold for referral for any patient with any suspicion of these conditions as the greatest challenge in their diagnosis is thinking of the disease. Once suspected biochemical confirmation or exclusion of the disease is usually straightforward.

Who should you refer to?

Ideally to a specialist endocrinologist or a local physician with a special interest in endocrinology.

It is better to see an endocrinologist first rather than a surgeon as the surgeon will need to refer the patient to an endocrinologist in any case. In some cases surgery is not recommended.

The endocrinologist can arrange all the specialist diagnostic tests to be completed prior to surgery enabling accurate monitoring of treatment to take place.

Life-long relationship

Life-long specialist monitoring will be required after initial treatment to ensure the appropriate and optimum balance of hormones is achieved. Many patients will be on life-long hormone replacement. In most cases a shared care protocol is established between the specialist and the patient’s GP.

Presenting Symptoms

These are the main symptoms; see individual sheets for additional information.

Main symptoms common to various tumour types

Type of tumour
Visual disturbanceNon-functioning (NF), acromegaly, Hyperprolactinaemia, Craniopharyngioma
Oligomenorrhoea or AmenorrhoeaNF, hyperprolactinaemia, Hypogonadism
Reduced libido in men & women, and reduced potency in menNF, hyperprolactinaemia, hypogonadism
HeadacheNF, acromegaly, hperprolactinaemia, craniopharyngioma
Tiredness and lack of energyNF, acromegaly, hypopituitarism (especially loss of GH and/or TSH and/or ACTH
 

Main symptoms specific to one or two types of tumour
Coarsening of facial featuresAcromegaly
Enlarged hands and feet, growth of the jawAcromegaly
Carpal Tunnel SyndromeAcromegaly
Excessive sweating and oily skinAcromegaly
Sleep apnoeaAcromegaly
Moon face - particularly filling in of the temporal fossaCushing's
Weight gain - central obesityCushing's
Muscle wasting and proximal myopathy (patients have difficulty standing from a seated position without use of arms)Cushing's
Thin skin - tendency to bruiseCushing's
Hirsutism (caused by androgen excess)Cushing's
Violaceous striaeCushing's
HypertensionAcromegaly, Cushing's
DiabetesAcromegaly, Cushing's
Osteoporosis and fracturesCushing's
Psychiatric disturbance (often characterised by amplification of previous personality traits)Cushing's
GalactorrhoeaHyperprolactinaemia
Growth retardation in childrenAny pituitary tumour causing hypopituitarism and Growth hormone Deficiency (GHD), craniopharyngioma
In adults: excessive tiredness, muscle weakness, lack of drive, impaired quality of lifeHypopituitarism - GH deficiency
Tired, difficulty recovering from minor illnessHypopituitarism - (ACTH, Cortisol deficiency), craniopharyngioma
Weight gain, decreased energy, sensitivity to cold, constipation, dry skinHypopituitarism - TSH deficiency
Pale appearance, weight loss, low blood pressure, dizziness, tiredness, 'collapse' during intercurrent illnessHypopituitarism - ACTH deficiency
Thirst, polydipsia, polyuria and nocturiaHypopituitarms - AVP deficiency - Diabetes Insipidus, craniopharyngioma
Delayed or arrested puberty, and very occasionally precocious pubertyCraniopharyngioma
Dyspareunia and hot flushes in womenHypogonadism

Absence of our incomplete sexual development:

  • lack of genital enlargement
  • lack of pubic / axillary hair and beard growth
  • lack of muscle development
  • lack of sexual interest
  • failure of the voice to break
  • spermatogenesis will not be initiated and infertility is the general rule
Pre-pubertal onset of Testosterone defiency - male hypoganidsm

Poorly maintained established secondary sexual characteristics:

  • tiredness
  • reduced libido and sexual functioning
  • reduced body and facial hair and muscle mass, infertility
Post-pubertal onset of testosterone deficiency - male hypogonaidsm

Last Updated ( Tuesday, 14 November 2006 )